E2F1-CDK1 pathway activation in kanamycin-induced spiral ganglion cell apoptosis and the protective effect of CR8

Yu-ying Liu,Guo-peng Wang,Zhe Peng,Jing-ying Guo,Qian Wu,Jing Xie,Shu-sheng Gong

Neuroscience Letters（2016）

引用 11|浏览6

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摘要

•Activation of the E2F1-CDK1 pathway and cell cycle re-entry contributes to the apoptosis of spiral ganglion cells (SGCs).•CR8 inhibits the E2F1-CDK1 pathway and down-regulates cleaved caspase-9 to potentially protect SGCs from apoptosis.•This is the first study focusing on the E2F1-CDK1 pathway and cell cycle re-entry in SGC apoptosis.

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关键词

Cochlear,Spiral ganglion cells,Apoptosis,E2F1,CDK1,CR8

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