Periodontal Ligament Stem Cells for Periodontal Regeneration

Periodontal tissue is susceptible to chronic periodontal disease, which results in irreversible tissue destruction. Adult stem cells can be obtained from the periodontal ligament of the periodontium. Stem cells from the periodontal ligament (PDLSCs) are promising for periodontal regeneration because they can undergo guided differentiation under specialized conditions. Currently, growth factors and scaffolds are used for differentiation and clinical application of PDLSCs. In this review, characteristics of PDLSCs and related factors are selectively analyzed.