Population variation in anti-S. aureus IgG isotypes influences surface protein A mediated immune subversion

Julia Whitehouse,Amy Flaxman,Christine Rollier,Matthew K. O'Shea,Joanne Fallowfield,Michael Lindsay,Frances Gunner,Kyle Knox,David H. Wyllie,Yuko Yamaguchi

Vaccine（2016）

引用 9|浏览23

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摘要

•There is marked variation in anti-S. aureus antibodies between healthy humans.•Serum IgG1 against S. aureus surface antigens declines as adults age.•High anti-S. aureus IgG3 levels bypass bacterial subversion of phagocyte function.•Properties of IgG subclasses should be considered in S. aureus vaccine development.

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关键词

Staphylococcus aureus,Immunosenescence,Antibody,Protein A,Vaccine

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