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Transcription factor Fli-1 positively regulates lipopolysaccharide-induced interleukin-27 production in macrophages

Peng Gao,Ming Yuan,Xianwei Ma,Wei Jiang,Lingxi Zhu,Mingyue Wen, Jing Xu,Qiuyan Liu,Huazhang An

Molecular Immunology（2016）

Cited 7|Views11
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Abstract
•LPS induces Fli-1 expression in macrophages.•Fli-1 is critical for LPS-induced IL-27 production in macrophages.•LPS induces Fli-1to bind IL-27 p28 promoter.•Fli-1 activates IL-27 p28 promoter cooperatively with IRF1.
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Key words
Fli-1,IRF1,MyD88,TFs,TLR,TRIF
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