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A significant role for tumor necrosis factor in Nlrp3 inflammasomeopathies

Matthew D. McGeough,Alexander Wree,Carla A. Peña,Maria Eugenia Inzaugarat,Ariel E. Feldstein,Hal M. Hoffman

Pediatric Rheumatology（2015）

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Abstract
The NLRP3 inflammasome is a protein complex responsible for caspase-1 dependent maturation of the pro-inflammatory cytokines IL-1β and IL-18. Gain of function missense mutations in NLRP3 cause the disease spectrum known as cryopyrin-associated periodic syndromes (CAPS).
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Key words
Etanercept, NLRP3 Inflammasome, Autoinflammatory Disease, Myeloid Cell Lineage, Marked Splenomegaly
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