Total synthesis and antiproliferative/cytotoxic profiling of 2-epi-jaspine B.

Eva Mezeiová,Miroslava Martinková,Kvetoslava Stanková,Milica Fabišíková,Jozef Gonda,Martina Pilátová,Gabriela Gönciová

Carbohydrate Research（2016）

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摘要

•The convergent total synthesis of 2-epi-jaspine B was developed.•The cornerstone of this strategy was the substrate-directed Overman rearrangement.•Chemical correlations of the key intermediates were performed.•The target 2-epi-jaspine B exhibited significant antiproliferative/cytotoxic activity.

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关键词

Anhydrophytosphingosines,Jaspine B,2-epi-Jaspine B,Overman rearrangement,Antiproliferative/cytotoxic activity

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