Active membrane cholesterol as a physiological effector
Chemistry and Physics of Lipids(2016)
Abstract
•Membrane sterols not complexed with polar lipids are “active” (very interactive).•Active cholesterol is a feedback signal that regulates cellular cholesterol levels.•Cholesterol interacts with a variety of transporter, channel and receptor proteins.•The function of several of these proteins responds acutely to active cholesterol.•Active cholesterol may thus be an important regulator of many cellular processes.
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Key words
ABCA1,ABCG1,CRAC,ER,GABA,GPCR,HDL,HMGR,HPCD,MBCD,NPC1,NPC1L1,NPC2,OSBP,ORP,PFO,Scap,StAR,START,SREBP
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