Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice

•mEH metabolites may not be driving the overall toxicity of NA for known tumor sites.•The mEH pathway may be partially responsible for cytotoxicity in extrapulmonary airways.•Acute exposure to naphthalene causes cytotoxicity in all airway generations at 5ppm.•Female mice may be more susceptible to naphthalene acute toxicity than males.