Evaluation of antioxidant activity of klotho in hemodialysis patients and renal transplant recipients
Urmia medical journal(2015)
Abstract
The aim of this study was to evaluate serum levels of antioxidant property Klotho
by examining 8-hydroxy-2'- deoxyguanosine (8-OHdG), as a marker of oxidative damage in nucleic
acids in patients with hemodialysis and kidney transplantation.
Materials & Methods: Serum samples from 45 patients undergoing hemodialysis and 45 patients with
stable renal transplant recipients were collected. Klotho levels, 8OHdG, iPTH and vitamin D (25 (OH)
D) were measured using standard methods.
Results: Klotho level in hemodialysis patients was significantly higher (p≤0.001). Considering the
serum levels (8-OHdG), there was no significant difference between the two groups (p=0.242). Serum
parathyroid hormone levels in hemodialysis patients was significantly higher while the correlation
between serum levels of iPTH and Klotho in none of the two groups were observed.
Conclusion: It seems that high levels of Klotho in hemodialysis patients is a secondary response to high
levels of parathyroid hormone, or just due to the use of immunosuppressive drugs in renal transplant
recipients
MoreTranslated text
Key words
antioxidant activity,klotho,hemodialysis patients
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