Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling

•Adolescent caffeine consumption increases anxiety-related behavior in adulthood.•Withdrawal from adolescent caffeine consumption increases blood corticosterone levels in adulthood.•Adolescent caffeine consumption decreases adrenal gland sensitivity in adulthood.•Adolescent caffeine consumption increases basal c-fos expression in the paraventricular nucleus of the hypothalamus in adulthood.•Adolescent caffeine consumption increases basal Crf expression in the central nucleus of the amygdala in adulthood.