A new biodegradable polymeric nanoparticle formulation containing Syzygium cumini: Phytochemical profile, antioxidant and antifungal activity and in vivo toxicity

Paula E.R. Bitencourt,Luana M. Ferreira,Lariane O. Cargnelutti,Laura Denardi,Aline Boligon,Michelli Fleck,Ricardo Brandão,Margareth L. Athayde,Letícia Cruz,Régis A. Zanette,Sydney H. Alves,Maria B. Moretto

Industrial Crops and Products（2016）

Cited 50|Views12

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Abstract

•Development of polymeric nanoparticles with ASc compatible with nanometric system.•Phytochemical characterization quantify phenolic compounds in NPASc.•DPPH and FRAP tests showed the equivalency between ASc and NPASc.•NPASc showed capacity to inhibit ox-LDL particle and moderate effect against fungi.•ASc and NPASc did not show toxicity in the Artemia salina test and in rats.

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Key words

Nanotechnology,Aqueous extract,Oxidative stress,Diabetes complications,Toxicity

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