Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo.

Helena Dračínská,František Bárta,Kateřina Levová, Alena Hudecová,Michaela Moserová,Heinz H. Schmeiser,Klaus Kopka,Eva Frei,Volker M. Arlt,Marie Stiborová

Toxicology（2016）

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摘要

•Oxidation and reduction of aristolochic acid I (AAI) dictate its (geno)toxicity in vivo.•Cytochrome P450 (CYP) 1A1 and 1A2 are induced in rats treated with Sudan I and AAI.•Induced CYP1A enzyme activity resulted in decreased AAI-DNA adduct levels in vivo.•CYP1A1 and 1A2 mainly detoxify AAI and attenuate its genotoxicity in vivo.

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AA,AAI,AAII,AAIa,AAN,BEN,bw,cT,CYP,dA-AAI,dA-AAII,dG-AAI,HPLC,HUFs,MROD,NQO1,POR,PEI-cellulose,RAL,RT-PCR,r.t.,SD,TLC,UUC,UV–vis

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