RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1

Attila Szabo,Tunde Fekete,Gabor Koncz,Brahma V. Kumar,Kitti Pazmandi,Zsofia Foldvari,Balazs Hegedus,Tamas Garay,Attila Bacsi,Eva Rajnavolgyi,Arpad Lanyi

Cellular Signalling（2016）

引用 18|浏览27

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摘要

•RIG-I exerts anticancer activity in BRAF-mutant melanoma via controlling IFNβ production and MAPK signaling.•RIG-I activation results in MKP-1-mediated cytostatic effect in BRAF-mutant melanoma.•RIG-I/MKP-1-mediated inhibition of cellular proliferation involves p38-HSP27, c-Jun and rpS6 MAPK pathways.

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关键词

RIG-I,MAPK,MKP-1/DUSP1,BRAF,Melanoma,Proliferation

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