Smoking status affects VRI assissted prediction of postoperative FEW1 and D-L,D-CO in patients th lung cancer

It is unclear whether smoking cessation following surgery influences calculation of predicted postoperative (ppo) values of lung function indices. Aim : To investigate the influence of smoking status on the accuracy of ppoFEV1 and ppoD L,CO prediction by means of vibration response imaging (VRI) in patients with lung cancer. Patients and methods : Thirty seven patients with non small cell lung cancer aged 60.6±8.0 years, 40.5±11.3 pack/years(mean±SD) referred for anatomical lung resection were studied. They underwent comprehensive spirometry and diffusion measurements (MasterScreen Diffusion, E. Jaeger, Germany) and vibration response imaging (VRIxp, DeepBreeze, Or-Akiva, Israel) before and approx. 30 days after the resection. The calculation of the ppo values was carried out with proprietary software - O-Plan. Results : Twenty eight lobectomies and 9 pneumonectomies were performed in the studied population (26 males/11 females). For the whole grouppredicted postoperative values and the actually measured FEV1 and D L,CO had very good agreement (r=0.846; p L,CO (52.2±18.5 vs 59.1±16.8; p Conclusion : In current smokers VRI tends to underestimate the values of both FEV1 and D L,CO compared with non-smokers. Developing a correction coeficient would be beneficial in patients with borderline lung function.