Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research(2016)
Abstract
•Lovastatin protects keratinocytes from IR- and Doxo-induced apoptosis.•Doxorubicin-induced formation of DSBs is reduced by statin.•Lovastatin reduces residual DNA damage following IR and Doxo treatment.•Activation of ATR/Chk1 signaling by IR and Doxo is attenuated by statin.•Protection by lovastatin involves proliferation-dependent and -independent mechanisms.
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Key words
53BP1,ATM,ATR,Chk,DSB,DDR,DNA-PKcs,Doxo,5-FU,γH2AX,HU,IR,JNK,Kap1,Lova,NF-κB,PARP,PI3K,ROS,RPA,SAPK,SSB
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