Spiranoid withanolides from Jaborosa odonelliana and Jaborosa runcinata

Two new spiranoid withanolides, (20R,22R,23R)-12 beta,17 beta ,22-trihydroxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (3) and (23R)-5 alpha,6 beta,12 beta,21-tetrahydroxy-1,22-dioxo-12,23-cycloergosta-2,17,24-trien-26,23-olide(4)were isolated from plants of Jaborosa odonelliana and Jaborosa runcinata, respectively. Compounds 3 and 4 were characterized by a combination of spectroscopic methods (ID and 2D NMR, MS) and molecular modelling.