IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala.

Reesha R Patel,Sophia Khom,Michael Q Steinman,Florence P Varodayan,William B Kiosses,David M Hedges,Roman Vlkolinsky,Tali Nadav,Ilham Polis,Michal Bajo,Amanda J Roberts,Marisa Roberto

Brain, Behavior, and Immunity（2019）

引用 34|浏览65

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摘要

•Chronic ethanol exposure increased IL-1β expression in CeA neurons and microglia.•IL-1β bi-directionally modulated GABA transmission in naïve, Non-Dep and Dep mice.•IL-1R1 regulation of basal GABAergic transmission was unaltered by chronic ethanol.•IL-1β and IL-1ra did not modulate acute ethanol’s facilitation of GABA release.

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关键词

IL-1β,IL-1R1,IL-1ra,IL-1RAcP,CeA,Non-Dep,Dep,CIE-2BC,mIPSC,sIPSC

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