Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells.

Shraddha Sharma,Jianmin Wang,Emad Alqassim,Scott Portwood,Eduardo Cortes Gomez,Orla Maguire,Per H Basse,Eunice S Wang,Brahm H Segal,Bora E Baysal

Genome biology（2019）

引用 58|浏览38

暂无评分

摘要

APOBEC3G is an endogenous RNA editing enzyme in primary natural killer cells and lymphoma cell lines. This RNA editing is induced by cellular crowding and mitochondrial respiratory inhibition to promote adaptation to hypoxic stress.

查看译文

关键词

APOBEC3,Cell stress,Epitranscriptome,Gene knockdown,Hypoxia,Innate immune cells,Mitochondria,NK cells,RNA editing

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要