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Klf4 Regulates Corneal Epithelial Cell Cycle Progression By Suppressing Canonical Tgf-Beta Signaling, And Upregulating Cdk Inhibitors P16 And P27

Anil Tiwari,Sudha Swamynathan,Nicholas Alexander,John Gnalian,Shenghe Tian,Paul R Kinchington,Shivalingappa K Swamynathan

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE（2019）

Cited 13|Views9
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Abstract
Collectively, these results demonstrate that KLF4 regulates CE cell cycle progression by suppressing canonical TGF-β signaling and overcomes the undesirable concomitant decrease in TGF-β-dependent CDK inhibitors p16 and p27 expression by directly upregulating them.
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Key words
KLF4, TGF-beta, SMAD, EMT, corneal epithelium, squamous neoplasia
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