CVm6A: A Visualization and Exploration Database for m⁶As in Cell Lines.

N6-methyladenosine (m(6)A) has been identified in various biological processes and plays important regulatory functions in diverse cells. However, there is still no visualization database for exploring global m(6)A patterns across cell lines. Here we collected all available MeRIP-Seq and m(6)A-CLIP-Seq datasets from public databases and identified 340,950 and 179,201 m(6)A peaks dependent on 23 human and eight mouse cell lines respectively. Those m(6)A peaks were further classified into mRNA and lncRNA groups. To better understand the potential function of m(6)A, we then mapped m(6)A peaks in different subcellular components and gene regions. Among those human m(6)A modification, 190,050 and 150,900 peaks were identified in cancer and non-cancer cells, respectively. Finally, all results were integrated and imported into a visualized cell-dependent m(6)A database CVm6A. We believe the specificity of CVm6A could significantly contribute to the research for the function and regulation of cell-dependent m(6)A modification in disease and development.