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The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons.

Ruoqi Gao,Colleen R Zaccard,Lauren P Shapiro,Leonardo E Dionisio,Maria Dolores Martin-de-Saavedra,Nicolas H Piguel,Christopher P Pratt,Katherine E Horan,Peter Penzes

Neuroscience Letters（2019）

Cited 14|Views37
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Abstract
•CNTNAP2, CASK, and GluA1 participate in a protein complex in vivo.•SIM imaging reveals endogenous CNTNAP2, CASK, and GluA1 largely associate in a tripartite manner.•Knockdown of either CNTNAP2 or CASK leads altered total GluA1 levels and localization in mature interneuron dendrites.
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Key words
Autism spectrum disorders,Schizophrenia,Language disorders,AMPA receptors,Neuropsychiatric disorders,Cntnap2,Excitatory-inhibitory balance,Structured illumination microscopy,Dendrites,Mechanism
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