New glycosylsphingolipids fromPsychotria serpensL

In clinical,Psychotria serpensL. was often substitute forCaulis trachelospermito treat cancer in China. Meanwhile, EtOAc and n-BuOH fractions of MeOH extract ofP. serpensL. show power activity against H460, HepG2, Hela, and PC9/GR cell lines, and no toxic effects against normal 16HBE cell lines. In our ongoing search for bioactive novel compounds from Chinese material medica, one new type of glycosylsphingolipids Psychotramide (1a-1c) were isolated fromP. serpensL., and their structures were identified through spectroscopic techniques including NMR (1D and 2D) and MS (LC-MS, and GC-MS).