Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis.

Lisa Zhou,Alexandra Leonard,Ana B Pavel,Kunal Malik,Aishwarya Raja,Jacob Glickman,Yeriel D Estrada,Xiangyu Peng,Ester Del Duca,Juan Sanz-Cabanillas,Juan Ruano,Hui Xu,Ning Zhang,Huei-Chi Wen,Juana Gonzalez,Sandra Garcet,James G Krueger,Emma Guttman-Yassky

Journal of Allergy and Clinical Immunology（2019）

引用 86|浏览39

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摘要

The adult AD profile varies with age. While T1/T17-skewing decreases in both AD and controls, AD shows unique decreases in T2/T22 polarization, and normalization of epithelial abnormalities. Thus, age-specific treatment approaches may be beneficial for AD.

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关键词

Atopic dermatitis,biomarker,TH1,TH2,TH17,TH22,hyperplasia,loricrin,filaggrin,aging,skin

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