A multi-substrate screening approach for the identification of a broadly applicable Diels–Alder catalyst
NATURE COMMUNICATIONS(2019)
Abstract
When developing a synthetic methodology, chemists generally optimize a single substrate and then explore the substrate scope of their method. This approach has led to innumerable and widely-used chemical reactions. However, it frequently provides methods that only work on model substrate-like compounds. Perhaps worse, reaction conditions that would enable the conversion of other substrates may be missed. We now show that a different approach, originally proposed by Kagan, in which a collection of structurally distinct substrates are evaluated in a single reaction vessel, can not only provide information on the substrate scope at a much earlier stage in methodology development, but even lead to a broadly applicable synthetic methodology. Using this multi-substrate screening approach, we have identified an efficient and stereoselective imidodiphosphorimidate organocatalyst for scalable Diels–Alder reactions of cyclopentadiene with different classes of α , β -unsaturated aldehydes.
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Key words
Asymmetric catalysis,Combinatorial libraries,Organocatalysis,Science,Humanities and Social Sciences,multidisciplinary
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