Metabolism of nivalenol and nivalenol-3-glucoside in rats.

Heidi E Schwartz-Zimmermann, Sabina B Binder,Christian Hametner,Eugènia Miró-Abella,Christiane Schwarz,Herbert Michlmayr, Nicole Reiterer,Silvia Labudova,Gerhard Adam,Franz Berthiller

Toxicology Letters（2019）

Cited 9|Views15

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Abstract

•Characterization of 7 novel nivalenol (NIV)- and NIV-3-glucoside (NIV3 G) metabolites in rats.•Development of LC–MS/MS based methods for analysis of NIV(3 G) metabolites in rat excrements.•Similar metabolization of NIV and deoxynivalenol in rats, but with different metabolite patterns.•NIV3 G is largely hydrolyzed in the GI tract of rats, but also extensively further metabolized.•The systemic exposure to NIV is roughly 30 times lower after NIV3 G consumption than after NIV dosage.

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Key words

b.w.,NIV,NIV3G,NIVS 1,NIVS 2,NIVS 3,NIV3GS 2,NIV-3-GlcAc,DNIV,DNIVS 2,DNIV-3-GlcAc,DON,DON3G,DONS 1,DONS 2,DONS 3,MeOH,ACN,ELSD,RLM,RSD,LOD,LOQ

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