Metabolic studies of synaptamide in an immortalized dopaminergic cell line.

Shilpa Sonti,Mansi Tolia,Richard I Duclos,Ralph H Loring,Samuel J Gatley

Prostaglandins & Other Lipid Mediators（2019）

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摘要

•Synaptamide synthesis does not take place in N27 dopaminergic cells.•Hydrolysis of synaptamide drives its uptake into N27 cells.•FAAH activity does not impact synaptamide uptake into differentiating N27 cells.•FAAH is less effective in hydrolyzing synaptamide than anandamide.

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关键词

DHA,AA,FAAH,[αβ-14C2],[αβ-14C2],[1-14C-DHA],[1-14C-AA],N27 cells

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