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Leukotriene B 4 modulation of murine dendritic cells affects adaptive immunity.

Marco Antonio Pires-Lapa,Marianna Mainardi Koga,Ildefonso Alves da Silva,Luciano Ribeiro Filgueiras,Sonia Jancar

Prostaglandins & Other Lipid Mediators（2019）

Cited 7|Views26
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Abstract
•Murine BM-DCs produce and respond to LTB4, upregulating BLT-1 expression.•LTB4 stimulation increased CD86 expression in BM-DCs and enhanced their T cell priming activity.•BM-DCs exposed to LTB4 can favor Th2/Treg adaptive immune responses.
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Key words
Leukotriene B4,Dendritic cells,Adaptive immunity
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