Francisella tularensis Transmission by Solid Organ Transplantation, 2017 1 .
EMERGING INFECTIOUS DISEASES(2019)
摘要
In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. F tularensis subsp. tularensis (clade A2) was cultured from archived spleen tissue from the donor and blood from both kidney recipients. Whole-genome multilocus sequence typing indicated that the isolated strains were indistinguishable. The heart recipient remained seronegative with negative blood cultures but had been receiving antimicrobial drugs for a medical device infection before transplant. Two lagomorph carcasses collected near the donor's residence were positive by PCR for F tularensis subsp. tularensis (clade A2). This investigation documents F tularensis transmission by solid organ transplantation.
更多查看译文
关键词
Francisella tularensis,Tularemia,United States,bacteria,biological warfare,bioterrorism and preparedness,laboratory infection,prevention and control,tissue donors,transplant,transplantation
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要