A Straightforward Synthesis of Functionalized -Perhydroisoquinolin-1-ones.
MOLECULES(2019)
摘要
Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones.
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关键词
5,6-dihydro-2(1H)-pyridone,Nazarov reagents,perhydroisoquinoline,Michael addition,stereoselectivity
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