NO/ET-1及HCY水平对重度OSAHS患者认知功能障碍的诊断效能
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery(2018)
Abstract
目的:探讨血清同型半胱氨酸(HCY)和一氧化氮(NO)与内皮索-1(ET-1)比值对重度OSAHS患者认知功能障碍的诊断效能,为干预治疗重度OSAHS伴有认知功能障碍的患者提供新的临床依据.方法:选取OSAHS患者86例,分为轻度组(22例)、中度组(23例)和重度组(41例),以健康体检者50例作为对照组.比较4组血清HCY及NO /ET-1水平,应用蒙特利尔认知评估量表评估重度OSAHS组轻度认知功能障碍的发生情况,分析重度OSAHS组患者血清HCY、NO/ET-1水平与认知功能的相关性.结果:重度OSAHS患者血清HCY水平[(32.28±3.92) μmol/L]均高于中度组[(26.34±1.05) μmnol/1L]及轻度组[(18.62±3.29)μmol/L];NO/ET-1水平(0.69±0.19)均低于中度组(2.76±0.28)及轻度组(3.98±0.37),均差异有统计学意义(P<0.05).血清HCY水平与MoCA总分及其亚项评分均呈负相关性(P<0.05),NO/ET-1与MoCA总分及其亚项评分均呈正相关性(P<0.05),HCY与NO/ET-1呈负相关性(P<0.05).血清HCY及NO/DT-1水平预测重度OSAHS患者认知功能障碍的ROC曲线下面积分别为0.788(95%CI0.654~0.921)、0.770(95%CI0.642~0.899).结论:血清HCY、NO/ET-1是重度OSAHS患者认知功能障碍形成的主要因素,HCY水平与认知损害程度呈负相关,NO/ET-1与认知损害程度呈正相关.
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Key words
NO,cognitive function,endothelin-1,homocysteine,montreal cognitive assessment,sleep apnea-hypopnea syndrome,obstructive
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