Preserved Cardiovascular Homeostasis Despite Blunted Acetylcholine-Induced Dilation in Mice with Endothelial Muscarinic M3 Receptor Deletion

Kjestine Schmidt,Alexandra Rhoden,Jakob Speiser,Birgit Geertz,June Uebeler,Thomas Eschenhagen,Cor de Wit

Acta physiologica (Oxford, England)（2019）

Cited 8|Views12

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Abstract

We conclude that AChM3R elicits the endothelium-dependent dilation upon ACh also in arterioles in vivo. Despite this prominent role, the endothelial deletion of AChM3R does not affect overall cardiovascular homeostasis. Thus, their physiologic function in endothelial cells remains obscure. This article is protected by copyright. All rights reserved.

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Key words

cardiac function,endothelium-dependent dilation,microcirculation,muscarinic acetylcholine receptor

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