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Tumor cells induce LAMP2a expression in tumor-associated macrophage for cancer progression.

Ruibo Wang,Yantong Liu, Li Liu,Mei Chen,Xiuxuan Wang,Jingyun Yang,Yanqiu Gong,Bi-Sen Ding,Yuquan Wei,Xiawei Wei

EBioMedicine（2019）

Cited 52|Views20
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Abstract
Our study suggests that tumor cells utilize LAMP2a-PRDX1/CRTC1 axis to modulate TAMs activation and promote tumor growth, reveals the role of LAMP2a in macrophage study and TAM-targeting tumor immunotherapy. FUND: National Natural Science Foundation of China (No. 81602492); National Key Research and Development Program of China (No. 2016YFA0201402).
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Key words
LAMP2a,Tumor-associated macrophage,Chaperone-mediated autophagy,Macrophage activation,Tumor microenvironment
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