A Population-wide study of electrocardiographic (ECG) norms and the effect of demographic and anthropometric factors on selected ECG characteristics in young, Southeast Asian males-results from the Singapore Armed Forces ECG (SAFE) study.

Background Routine use of pre-participation electrocardiograms (ECGs) has been used by the Singapore Armed Forces, targeting early detection of significant cardiac diseases. We aim to describe the impact of demographic and anthropometric factors on ECG variables and establish a set of electrocardiographic reference ranges specific to a young male multiethnic Southeast Asian cohort. Methods and results Between November 1, 2009, and December 31, 2014, 144,346 young male conscripts underwent pre-participation screening that included a 12-lead ECG, demographic and anthropometric measurements. The Chinese population had the longest PR interval (146.7 +/- 19.7 vs. 145.21 +/- 19.2 in Malays vs. 141.2 +/- 18.8 ms in Indians), QRS duration (94.5 +/- 9.8 vs. 92.6 +/- 9.7 in Malays vs. 92.5 +/- 9.4 ms in Indians) and QTcB interval (408.3 +/- 21.3 vs. 403.5 +/- 21.6 in Malays vs. 401.2 +/- 21.4 ms in Indians) (all p < 0.001). Body mass index (BMI) >25 kg/m(2) and body fat >25% were independently associated with lower prevalence of increased QRS voltage on ECG. Systolic blood pressure of >140 mmHg or diastolic blood pressure of >90 mmHg independently increased the prevalence of increased QRS voltage on ECG. Conclusions Electrocardiographic parameters vary across different ethnicities and in comparison with international norms. In our population, diagnosis of increased QRS voltage by ECG is less prevalent with obesity and increased body fat. Further analysis of gold standard measurements for the diagnosis of LVH in our population is ongoing, to improve the accuracy of the ECG screening process.