Stromal vascular fraction cell therapy for osteoarthritis in elderly: Multicenter case-control study.

Osteoarthritis (OA) is the most common type of degenerative joint disease often requiring joint replacement as a current available therapeutic option. A basis of OA is degeneration and chronic inflammation of the connective tissues of joints, including the cartilage due to a long-term damaging of chondroblasts, chondrocytes and extracellular matrix1 caused by oxidative stress, inflammatory factors and mitochondrial dysfunction causing DNA damage.2 Elderly people are the most vulnerable population as effects of ageing including degenerative changes and chronic inflammation of joints are more pronounced.