Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases.
Bioorganic & Medicinal Chemistry Letters（2019）
Abstract
•Calixarene-based phosphinic inhibitors of PTP1B were synthesized.•The potency and selectivity of the inhibitors depend on scaffold type.•The inhibitors can bind to active site of PTP1B.
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Key words
Protein tyrosine phosphatase,Inhibition,Calix[4]arene,Thiacalix[4]arene,Sulfonylcalix[4]arene,Phosphinic acids,Molecular docking
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