3-Hydroxyisoindolin-1-one derivates: Synthesis by palladium-catalyzed CH activation as BRD4 inhibitors against human acute myeloid leukemia (AML) cells.
Bioorganic Chemistry（2019）
Abstract
•Novel 3-Hydroxyisoindolin-1-One BRD4 inhibitors were designed and synthesized via palladium-catalyzed CH activation.•Molecular docking was performed.•Cell proliferation inhibition was evaluated in the LNcap-1, HL-60 and MV4-11 cell lines.•Induce apoptosis via the mitochondrial pathways in leukemia cells.
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Key words
BRD4 inhibitors,Molecular docking,CH activation,Anticancer
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