Characterization of folding-sensitive nanobodies as tools to study the expression and quality of protein particle immunogens.

Vanina Alzogaray,Mariela Urrutia,Paula Berguer,Andrés Rossi,Vanesa Zylberman,Romina Pardo,Hernán R Bonomi,Fernando A Goldbaum

Journal of Biotechnology（2019）

引用 1|浏览17

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摘要

•Four families of nanobodies were generated that recognize Brucella spp. lumazine synthase (BLS) in its native state only.•These nanobodies also recognize folded BLS ex vivo.•Conformation-sensitive Nbs are good molecular probes for quality control of vaccines.

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关键词

Vaccine,Protein particle,Quality control,Brucella lumazine synthase,Nanobodies,Conformational probes

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