Vitamin D (1,25(OH)D3) induces α-1-antitrypsin synthesis by CD4 T cells, which is required for 1,25(OH)D3-driven IL-10.

Sarah Dimeloe,Louise V Rice, Hebe Chen,Charlotte Cheadle,John Raynes,Paul Pfeffer,Paul Lavender,David F Richards,Mun Peak Nyon,James M McDonnell,Claudia Kemper,Bibek Gooptu,Catherine M Hawrylowicz

The Journal of Steroid Biochemistry and Molecular Biology（2019）

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摘要

•Human CD4+ T cells exposed to 1,25(OH)2D3 secrete α-1-antitrypsin – representing a novel cellular source of this protein.•α-1-Antitrypsin promotes IL-10 secretion by human CD4+ T cells, via direct interaction with complement C3a.•1,25(OH)2D3 is unable to increase IL10 transcription in CD4+ T cells from α-1-antitrypsin-deficient individuals.•Therefore, autocrine α-1-Antitrypsin is required for 1,25(OH)2D3-driven IL-10 expression.

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关键词

Immune regulation,IL-10,α-1-Antitrypsin,Complement,C3a

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