Review of Transcriptomic Responses to Hexavalent Chromium Exposure in Lung Cells Supports a Role of Epigenetic Mediators in Carcinogenesis.

•Review of Cr(VI)-induced transcriptomic alterations in the lung was conducted.•372 genes were identified with Cr(VI)-induced modulated expression in more than one study.•Cell proliferation signaling was increased, and DNA damage repair signaling was suppressed.•DNA methylation, histone proteins/marks, and microRNAs were predicted to regulate a portion of the signaling responses.•This study provides mechanistic and mode of action data relevant to inhalation cancer risk assessment of Cr(VI).