Baseline Living Donor Kidney Volume and Function Associate with 1-Year Post-Nephrectomy Kidney Function.

Living donors may develop kidney dysfunction more often than equally healthy populations. The purpose of this study was to determine whether computed tomography-assessed remaining kidney volume indexed to body surface area (RKV/BSA) was associated with 1-year post-nephrectomy renal function independent of baseline renal function. Using multivariable regression, we modeled 1-year estimated glomerular filtration rate (eGFR) and eGFR <60 mL /min/1.73 m(2) and considered pre-determined baseline eGFR subgroups in 151 consecutive donors. Mean +/- SD baseline age, eGFR, RKV, BSA, and RKV/BSA were 38 +/- 11 years, 97 +/- 16 mL/min/1.73 m(2), 153 +/- 29 mL, 1.9 +/- 0.2 m(2), and 80.0 +/- 12.8 ml/m(2), respectively; 50% were female and 94% were white. Mean baseline eGFR was greater with increasing RKV/BSA tertiles (92 +/- 14, 97 +/- 16, 107 +/- 16 mL/min/1.73 m(2); P < 0.001). Post-nephrectomy eGFR remained separated by RKV/BSA tertiles. At baseline, each SD greater RKV/BSA and eGFR was independently associated with higher adjusted 1-year eGFR by 2.4 and 9.2 mL/min/1.73 m(2). Each SD greater age associated with 2.2 mL/min/1.73 m(2) lower adjusted 1-year eGFR. Adjusted odds of 1-year eGFR <60 increased significantly for donors with RKV/BSA <80 mL/m(2). With baseline eGFR <90, probability of 1-year eGFR 80% with decreasing RKV/BSA values below 80 mL/m(2). Those with baseline eGFR >100 rarely developed 1-year eGFR 60 mL/m(2). RKV/BSA independently associated with 1-year eGFR <60, especially with lower baseline eGFRs. Additional studies should evaluate the predictive utility of this measure and its potential role in donor evaluations and informed consent.