hsa-miR-20a-5p attenuates allergic inflammation in HMC-1 cells by targeting HDAC4.

Yi Lu,Zhenjie Li,Baoqiang Xie,Yan Song, Xiaoqing Ye,Pingping Liu

Molecular Immunology（2019）

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摘要

•miR-20a was down-regulated in PMA/A23187-treated HMC-1 cells.•miR-20a inhibited pro-inflammatory cytokines but promoted IL-10 expression.•miR-20a targeted HDAC4 and suppressed its expression.

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关键词

miRNAs,HDAC4,TNF-α,IL-1β,IFN-γ,IL-10

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