Imidazolo and tryptophan-imidazolo hybrid derived ureas/thioureas as potent bioactive agents - SAR and molecular modelling studies.

•Syntheses of urea/thiourea derivatives of imidazolo and tryptophan-imidazolo hybrid.•Antioxidant, anti-inflammatory and antimicrobial activities were carried out.•Molecular modelling studies were carried out and correlated with biological results.•Correlation showed that EDGs & EWGs help in antioxidant & antimicrobial and anti-inflammatory activities respectively.