The T-type Ca 2+ Channel Ca v 3.2 Regulates Differentiation of Neural Progenitor Cells during Cortical Development via Caspase-3.

Paola Rebellato,Dagmara Kaczynska,Shigeaki Kanatani,Ibrahim Al Rayyes,Songbai Zhang,Carlos Villaescusa,Anna Falk,Ernest Arenas,Ola Hermanson,Lauri Louhivuori,Per Uhlén

Neuroscience（2019）

Cited 8|Views37

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Abstract

•Spontaneous Ca2+ activity in NPCs is regulated by the Cav3.2 gene Cacna1h.•Ca2+ active NPCs have enhanced caspase-3 activity, unrelated to apoptosis.•Cav3.2 inhibition decreases caspase-3 activity and suppresses NPC differentiation.•Cacna1h KO embryonic brains display attenuated spontaneous Ca2+ activity.•Cacna1h KO embryonic brains show impaired neocortical layer formation.

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Key words

spontaneous Ca2+ activity,Cacna1h,neural differentiation,caspase-3,T-type calcium channels

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