The T-type Ca 2+ Channel Ca v 3.2 Regulates Differentiation of Neural Progenitor Cells during Cortical Development via Caspase-3.
Neuroscience(2019)
Abstract
•Spontaneous Ca2+ activity in NPCs is regulated by the Cav3.2 gene Cacna1h.•Ca2+ active NPCs have enhanced caspase-3 activity, unrelated to apoptosis.•Cav3.2 inhibition decreases caspase-3 activity and suppresses NPC differentiation.•Cacna1h KO embryonic brains display attenuated spontaneous Ca2+ activity.•Cacna1h KO embryonic brains show impaired neocortical layer formation.
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Key words
spontaneous Ca2+ activity,Cacna1h,neural differentiation,caspase-3,T-type calcium channels
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