Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.

Livia Weijenborg Campos,Priscila Pini Zenatti,Leonardo Granato Pissinato, Gisele O Libanio Rodrigues,Leonardo Luís Artico, Thais Rafael Guimarães,Leticia Fröhlich Archangelo,Leandro Martínez,Andrew J Brooks,José Andrés Yunes

Blood（2019）

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摘要

TO THE EDITOR:The receptor for interleukin-7 (IL-7) is formed by the IL7RA and the IL2RG (γc) chains. IL-7 leads to the reciprocal phosphorylation of IL7RA-associated JAK1 and γc-associated JAK3, followed by phosphorylation of IL7RA and then STAT5 anchoring and activation. Constitutive signaling

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