Persistence of bactericidal antibodies 4 years after a booster dose of quadrivalent meningococcal diphtheria toxoid conjugate vaccine (MenACWY-D).

Corwin A Robertson,James Hedrick,Ehab Bassily,David P Greenberg

Vaccine（2019）

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摘要

•Waning protection after a primary dose of MenACWY has been demonstrated.•Earlier, we reported the safety and immunogenicity of a MenACWY-D booster.•We now report antibody persistence 4 years after a MenACWY-D booster.•Protective titers against all serogroups were seen in a majority of participants.•These findings support current ACIP recommendations for a MenACWY booster dose.

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Persistence of bactericidal antibodies 4 years after a booster dose of quadrivalent meningococcal diphtheria toxoid conjugate vaccine (MenACWY-D).

Persistence of bactericidal antibodies 4 years after a booster dose of quadrivalent meningococcal diphtheria toxoid conjugate vaccine (MenACWY-D).