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Effect of the TYK-2/STAT-3 pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate.

Wen Qi,Liting Zhou,Tianye Zhao,Shuang Ding,Qi Xu,Xu Han,Yaming Zhao,Xinyue Song,Tianyang Zhao,Xiaohan Zhang,Lin Ye

Molecular and Cellular Endocrinology（2019）

Cited 18|Views23
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Abstract
•We established 3T3-L1 precuisor adipocyte differentiation model.•We aimed to observe the effect of exposure to MEHP during cell differentiation and evaluated the effect of MEHP accumulation on lipid metabolism by the TYK2/STAT3 pathway.•We also tested the effect of mitochondrial STAT3 on lipid metabolism on 3T3-L1 cells.
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Key words
MEHP,TYK-2/STAT-3 pathway,Mitochondrial STAT-3,3T3-L1 adipocytes,ROS,Lipid metabolism
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