Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of Heparin-Binding EGF-like growth factor.
Acta Biomaterialia(2019)
Abstract
Functional biomaterials that are able to bind, stabilize and release bioactive proteins in a defined manner are required for the controlled delivery of such to the desired place of action, stimulating wound healing in health-compromised patients. Glycosaminoglycans (GAG) represent a very promising group of components since they may be functionally engineered and are well tolerated by the recipient tissues due to their relative immunological inertness.
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Key words
AC,Coll,CS,DF,D.S.,D.U.,ECM,EGF,EGFR,GAFF,GAG,HA,sHA,HB,HB-EGF,HEP,MD,PME,PDB,ps
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