Ba08: An Open-Label, Single-Arm, Non-Randomised, Phase 2 Trial Of Cisplatin, Methotrexate And Vinblastine (Cmv) For Pure Squamous Cell Cancer Of The Urinary Tract
PLOS ONE(2019)
摘要
BackgroundPure squamous cell carcinoma (SCC) of the urinary tract is rare in the UK and has a poor prognosis compared with transitional cell carcinoma (TCC). Cisplatin based chemotherapy has been shown to be effective in TCC.MethodsPatients with T3-T4, pelvic relapsed, nodal or metastatic SCC of the urinary tract were recruited into an open-label, single-arm, non-randomised, phase 2 trial evaluating the activity and safety of cisplatin, methotrexate and vinblastine (CMV) chemotherapy. CMV was given as three 21-day cycles of methotrexate 30mg/m(2) (day 1 & 8), vinblastine 4mg/m(2) (day 1 & 8) and cisplatin 100mg/m(2) (day 2).Results38 patients were recruited. Overall response was 39% (95% CI 24%, 55%)-13% CR and 26% PR. Median OS was 7.8 months (95% CI 3.4, 12.6) with 39% 1-year survival. Toxicity was acceptable.ConclusionCMV is well tolerated and active in patients with pure SCC of the urinary tract.
更多查看译文
关键词
pure squamous cell cancer,squamous cell cancer,cisplatin,urinary tract,open-label,single-arm,non-randomised
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要