Decreased diabetes risk over 9 year after 18-month ora l l-arginine treatment in midd le-aged subjects with impaired g lucose to lerance and metabo lic syndrome (extension eva luation of l-arginine study)

This study aimed to determine whether l-arginine supplementation lasting for 18 months maintained long-lasting effects on diabetes incidence, insulin secretion and sensitivity, oxidative stress, and endothelial function during 108 months among subjects at high risk of developing type 2 diabetes.