A web application and service for imputing and visualizing missense variant effect maps.
Bioinformatics (Oxford, England)(2019)
摘要
SUMMARY:The promise of personalized genomic medicine depends on our ability to assess the functional impact of rare sequence variation. Multiplexed assays can experimentally measure the functional impact of missense variants on a massive scale. However, even after such assays, many missense variants remain poorly measured. Here we describe a software pipeline and application to impute missing information in experimentally determined variant effect maps.
AVAILABILITY AND IMPLEMENTATION:http://impute.varianteffect.org source code: https://github.com/joewuca/imputation.
SUPPLEMENTARY INFORMATION:Supplementary data are available at Bioinformatics online.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要